/// <summary>
        /// CTRL+5事件Id
        /// </summary>
        private const int Ctrl5KeyEventId = 9000;


        [DllImport("user32.dll")]
        public static extern bool RegisterHotKey(IntPtr hWnd, int id, uint fsModifiers, uint vk);

        [DllImport("user32.dll")]
        public static extern bool UnregisterHotKey(IntPtr hWnd, int id);


        protected override void OnSourceInitialized(EventArgs e)
        {
            base.OnSourceInitialized(e);

            var handle = new WindowInteropHelper(this).Handle;
            var source = HwndSource.FromHwnd(handle);
            source?.AddHook(HwndHook);
            //真正注冊快捷鍵監(jiān)聽處理: 同時注冊數(shù)字鍵和小鍵盤的CTRL+5
            RegisterHotKey(handle, Ctrl5KeyEventId, (uint)ModifierKeys.Control, (uint)KeyInterop.VirtualKeyFromKey(Key.D5));
            RegisterHotKey(handle, Ctrl5KeyEventId, (uint)ModifierKeys.Control, (uint)KeyInterop.VirtualKeyFromKey(Key.NumPad5));
        }


        private IntPtr HwndHook(IntPtr hwnd, int msg, IntPtr wParam, IntPtr lParam, ref bool handled)
        {
            const int wmHotkey = 0x0312;

            switch (msg)
            {
                case wmHotkey:
                    switch (wParam.ToInt32())
                    {
                        case Ctrl5KeyEventId:
                            Debug.WriteLine("Win32監(jiān)聽CTRL+5成功");
                            break;
                    }
                    break;
            }

            return IntPtr.Zero;
        }


        protected override void OnClosing(CancelEventArgs e)
        {
            base.OnClosing(e);

            var handle = new WindowInteropHelper(this).Handle;
            //關(guān)閉窗口后取消注冊
            UnregisterHotKey(handle, Ctrl5KeyEventId);
        }

        public MainWindow()
        {
            InitializeComponent();
            KeyDown += MainWindow_KeyDown;
        }


        private void MainWindow_KeyDown(object sender, KeyEventArgs e)
        {
            if (Keyboard.Modifiers == ModifierKeys.Control && (e.Key == Key.D5 || e.Key == Key.NumPad5))
            {
                Debug.WriteLine("WPF的KeyDown事件監(jiān)聽CTRL+5成功"); ;
                e.Handled = true;
            }
        }

    <Window.CommandBindings>
        <CommandBinding Command="{x:Static local:Commands.Ctrl5Command}" Executed="Ctrl5Command_OnExecuted"/>
    </Window.CommandBindings>
    <Window.InputBindings>
        <KeyBinding Modifiers="Control" Key="D5"  Command="{x:Static  local:Commands.Ctrl5Command}" />
        <KeyBinding Modifiers="Control" Key="NumPad5"  Command="{x:Static  local:Commands.Ctrl5Command}" />
    </Window.InputBindings>

        private void Ctrl5Command_OnExecuted(object sender, ExecutedRoutedEventArgs e)
        {
            Debug.WriteLine("WPF的XAML綁定命令監(jiān)聽CTRL+5成功");
        }

    public static class Commands
    {
        public static ICommand Ctrl5Command { get; } = new RoutedCommand();
    }